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Lunedì 28 Gennaio 2019 12:00
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Aula F via pascoli
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Prof. Giorgio Schiro'
titoloevento
X-ray pulses for time-resolved experiments on photosensitive systems II - Ultrafast protein structural dynamics
abstract
Biological macromolecules are characterized by specific structural and dynamic
features that are at the basis of their biological activity. Understanding
macromolecular activity thus requires studying structural changes over time and on
various time-scales down to the femtochemistry regime. Time-resolved X-ray
scattering and diffraction permit tracking macromolecular conformational changes
along a photoinduced reaction pathway, and their characterization at the atomic
level of resolution. The temporal resolution is limited to 100 ps at synchrotrons.
The advent of X-ray free electron lasers (XFEL) has pushed the resolution to the sub-
ps regime, allowing ultrafast changes to be studied by time-resolved serial
femtosecond crystallography. I will show results from recent studies of light-
induced protein structural dynamics in model systems [1-2] and in photoactive
proteins on the femtosecond to millisecond time scale [3-5].

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